4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one
4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one
CAS: 1358715-18-0
Molecular Formula: C22H16F4N6O2
4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one - Names and Identifiers
4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one - Physico-chemical Properties
| Molecular Formula | C22H16F4N6O2 |
| Molar Mass | 472.4 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20℃ |
| Use | Fuzuopali is a poly (ADP-ribose) polymerase inhibitor (PARP) inhibitor potentially for the treatment of solid tumours. |
4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one - Reference
| Reference Show more | 1: Jiang X, Tao Y, Liu Y, Shi P, Li T, Sun F, Cao Y, Wang C. A Randomized, Open- label, Two-period Crossover Bridging Study on Fuzuloparib Capsules of Different Specifications in Healthy Chinese Volunteers. Br J Clin Pharmacol. 2021 Aug 10. doi: 10.1111/bcp.15035. Epub ahead of print. PMID: 34378245. 2: Lee A. Correction to: Fuzuloparib: First Approval. Drugs. 2021 Jul;81(10):1227. doi: 10.1007/s40265-021-01570-6. Erratum for: Drugs. 2021 Jul;81(10):1221-1226. PMID: 34245448. 3: Lee A. Fuzuloparib: First Approval. Drugs. 2021 Jul;81(10):1221-1226. doi: 10.1007/s40265-021-01541-x. Erratum in: Drugs. 2021 Jul 10;: PMID: 34118019. 4: Zhang Q, Kai J, Zhai Y, Xu N, Shentu J, Zhang Y, Liang Y, Wang Y, Wu L. The impact of rifampicin on the pharmacokinetics of fuzuloparib in healthy Chinese male volunteers. Br J Clin Pharmacol. 2021 May 25. doi: 10.1111/bcp.14926. Epub ahead of print. PMID: 34033139. |
4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.117 ml | 10.584 ml | 21.168 ml |
| 5 mM | 0.423 ml | 2.117 ml | 4.234 ml |
| 10 mM | 0.212 ml | 1.058 ml | 2.117 ml |
| 5 mM | 0.042 ml | 0.212 ml | 0.423 ml |
Last Update：2024-01-02 23:10:35
4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one - Reference Information
| biological activity | Fluzoparib(SHR3162,HS10160) is a potent Poly (ADP-ribose) polymer (PARP) inhibitors, with anti-tumor activity. |
| Target | TargetValue PARP () |
| Target | Value |
Last Update：2024-04-10 22:29:15
![4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one](http://res.chembk.com/assets/images/structure/1002215.gif)
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View History
4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one
4-[4-(methoxycarbonyl)-1H-pyrazol-1-yl]butanoic acid
Spiro[3H-indole-3,4'-piperidine], 1'-[(2R)-2-amino-1-oxo-3-(phenylmethoxy)propyl]-1,2-dihydro-1-(methylsulfonyl)-
Absin
6-Chloro-9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)-9H-purine
18909-18-7
(S)-3-PHENOXYBENZALDEHYDE CYANOHYDRIN
3,5-Bis(pyridin-4-yl)heptane-1,7-diol
2-Benzoxazolecarboxylic acid, 6-amino-
2-Pyrrolidinecarboxamide,N-(2-cyanoethyl)-5-oxo-,(-)-(9CI)
4-[4-(methoxycarbonyl)-1H-pyrazol-1-yl]butanoic acid
Spiro[3H-indole-3,4'-piperidine], 1'-[(2R)-2-amino-1-oxo-3-(phenylmethoxy)propyl]-1,2-dihydro-1-(methylsulfonyl)-
Absin
6-Chloro-9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)-9H-purine
18909-18-7
(S)-3-PHENOXYBENZALDEHYDE CYANOHYDRIN
3,5-Bis(pyridin-4-yl)heptane-1,7-diol
2-Benzoxazolecarboxylic acid, 6-amino-
2-Pyrrolidinecarboxamide,N-(2-cyanoethyl)-5-oxo-,(-)-(9CI)